Dr Stephen John Middleton MA MD FRCP FAHE

Consultant Gastroenterologist

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Research

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Dr Middleton has an active research programme which currently focuses on the treatment of Inflammatory Bowel Disease (Crohn’s and Colitis) and the Irritable Bowel Syndrome. He has undertaken research in gastroenterology since 1990 and has made important contributions to the understanding and treatment of these conditions.

His research group is currently investigating the use of anti-TNF antibody treatment in ulcerative colitis as part of a Global study for which he is the Chief Investigator for the UK. He is also the UK Chief Investigator for the Global treatment registry for the treatment of ulcerative colitis.

Dr Middleton’s group have recently completed a study into a new steroid (predocol) which has far fewer side effects than the traditional steroids and this new medicine should soon  be widely available.  Much of the work concerning the dietary treatment of Crohn’s disease and irritable bowel syndrome has been undertaken in Cambridge and Dr Middleton has been involved in this area of research since 1990.

He has used and developed dietary treatments and Cambridge is widely recognised as a leading centre for these treatments. The mechanism by which these treatments work has long been a mystery but the recent identification of genes linked to Crohn’s disease, also identified at Cambridge have now thrown light on this area and suggest the benefit of the diet may be through it’s effect on the intestinal bacteria.
 
IBS : Dr Middleton has undertaken extensive research into the cause and treatment for the irritable bowel syndrome (IBS) which has predominantly focused on the dietary treatment of the condition. The Cambridge exclusion and fibre modification diets have long been successful treatments for IBS and avoid the need for drug therapy. These diets are very well establlshed and remain the most straightforward diets for treating IBS. 
 
Middleton Syndrome : Over the last few years Dr Middleton has been working on a new syndrome which is caused by a fall in blood sugar levels after eating, often associated by bloating,  fatique, cognitive impairment and nausea, which in some cases is preceded by diarrhoea. He has determined that this is caused by rapid gastric emptying and as he was the first person to identify the syndrome it has be named Middleton Syndrome. 

Much of his research has led to publications in scientific and medical journals.

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